布林佐胺联合噻吗洛尔治疗开角型青光眼的临床效果观察及安全性评价

目的:探讨布林佐胺联合噻吗洛尔治疗开角型青光眼的临床效果及安全性。方法:选择2016年9月至2018年9月在我院接受治疗的150例开角型青光眼患者,采用抽签法分为观察组(n=76)和对照组(n=74)。对照组给予噻吗洛尔治疗,观察组在对照组的基础上给予布林佐胺治疗。比较两组患者的临床疗效、治疗前后眼压、视野平均光敏度、视野平均缺损、视网膜神经纤维层厚度(RNFLT)、视盘盘沿面积(NRA)、泪膜破裂时间(BUT)、收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)及阻力系数(RI)水平的变化及并发症的发生情况。结果:治疗后,观察组和对照组总有效率分别为96.72%,79.66%,观察组显著高于对照组(P0.05);观察组眼压、视野平均光敏度、视野平均缺损水平及RI均显著低于对照组(P0.05),PSV、EDV、BUT显著高于对照组(P0.05)。两组并发症总发生率分别为3.95%、9.46%,差异无统计学意义(P0.05)。结论:布林佐胺联合噻吗洛尔用于开角型青光眼患者的效果显著,可有效改善患者眼压、视敏度,且安全性较高。

Curative Efficacy of Brinzolamine Combined with Timolol in the Treatment of Open Angle Glaucomaand Its Safety

ABSTRACT Objective: To study the curative efficacy of brinzolamine combined with timolol in the treatment of open angle glaucoma and its safety. Methods: 150 patients with open-angle glaucoma who were treated in our hospital from September 2016 to September 2018 were selected and divided into the observation group (n=76) and the control group (n=74) by lottery. The control group was treated with timolol, and the observation group was treated with brinzolamine on the basis of control group. The clinical curative effect, the average intraocular pressure, vision light sensitivity, average visual defect, retinal nerve fiber layer thickness (RNFLT) along the area (NRA), it appears, DVD disk rupture time (BUT), systolic peak velocity (PSV), end-diastolic velocity (EDV), the change of drag coefficient (RI) levels and the occurrence of complications were compared between the two groups before and after treatment. Results: After treatment, the total effective rate of observation group and control group was 96.72% and 79.66%, respectively, which was significantly higher in the observation group than that in the control group(P<0.05). The iop, average photosensitivity of visual field, average defect level of visual field and RI in the observation group were significantly lower than those in the control group(P<0.05), while the PSV, EDV and BUT were significantly higher than those in the control group(P<0.05). The total incidence of complications in the two groups was 3.95% and 9.46%, respectively, with no statistically significant difference(P<0.05). Conclusion: Brinzolamide combined with timolol has a remarkable effect on patients with open-angle glaucoma, which can effectively improve the intraocular pressure and visual acuity of the patients with high safety.