新型冠状病毒肺炎患者血清SAA、ESR、CRP检测结果分析

目的:分析新型冠状病毒肺炎(COVID-19)患者血清淀粉样蛋白A(SAA)、血沉ESR(ESR)、C-反应蛋白CRP(CRP)的临床价值。方法:以我院2020年1月至2020年2月确诊的COVID-19患者51例为实验组:其中重症患者21例,轻症患者30例,选取非感染患者30例为对照组。分析新型冠状病毒肺炎(COVID-19)患者血清SAA、ESR、CRP水平以及临床价值。结果:实验组SAA、ESR、CRP水平高于对照组(P0.05);重症组SAA、ESR、CRP水平高于轻症组(P0.05),由ROC曲线得知SAA、ESR、CRP预测COVID-19的AUC小于三者联合预测的AUC。结论:COVID-19的SAA、ESR、CRP水平会升高,三者联合预测为疾病评估、预测疾病发展的提供依据,值得临床进一步推广应用。

Analysis of Serum Amyloid A, Serum Sedimentation and C-reactive Protein in COVID-19 Patients

ABSTRACT Objective: To analyze of the clinical values of serum amyloid A (SAA), serum sedimentation (ESR) and c-reactive protein (CRP) in sera from COVID-19 patients. Methods: 51 patients with COVID-19 diagnosed in our hospital from January 2020 to February 2020 were involved as the experimental group. Among them, 21 severe patients, 30 mild patients, and 30 non-infected patients were treated as the control group. The levels of SAA, ESR and CRP were detected sera from COVID-19 patients. Results: The levels of SAA, ESR and CRP in the experimental group were higher than those in the control group (P<0.05).The levels of SAA, ESR and CRP in the severe group were higher than that in the mild group (P<0.05). According to the ROC curve, the AUC of SAA, ESR and CRP in the prediction of COVID-19 was lower than that in the combined detection of the three. Conclusion: The serum levels of SAA, ESR and CRP of COVID-19 will increase. The Combined detection of SAA, ESR and CRP can improve the accuracy of diagnosis of COVID-19. It provides the basis for clinical prediction and treatment to evaluate the disease and predict the development of the disease.