丙泊酚用于颅脑损伤手术患者的麻醉效果及对血清SOD、颅内压的影响

目的:分析丙泊酚用于颅脑损伤手术患者的麻醉效果及对血清超氧化物歧化酶(SOD)、颅内压的影响。方法:选择2017年3月-2019年3月我院收治的颅脑损伤手术患者100例纳入本次研究,根据麻醉方式分为观察组(n=51)和对照组(n=49)。对照组使用七氟烷进行麻醉诱导,观察组采用丙泊酚进行麻醉诱导。比较两组患者呼吸恢复时间、睁眼时间、拔管时间、术中心率,麻醉前(T0)、手术中(T1)、手术结束时(T2)时SOD、颅内压、心率(HR)、平均动脉压(MAP)、视觉模拟(VAS)评分、简易智能量表(MMSE)水平的变化情况及不良反应的发生情况。结果:观察组呼吸恢复时间、睁眼时间、拔管时间及术中心率均显著短于对照组,差异显著(P0.05);T0时,两组SOD、颅内压水平比较无显著差异;T1、T2时,两组SOD、颅内压水平均较T0时下降,且观察组SOD水平显著高于对照组,颅内压低于对照组(P0.05);T0时,两组HR、MAP水平比较无显著差异;T1、T2时,两组HR、MAP水平均较T0时升高,且观察组低于对照组(P0.05);术前,两组VAS、MMSE评分比较无明显差异;术后,两组VAS、MMSE评分水平均较T0时下降,且观察组MMSE评分水平均显著高于对照组,VAS评分水平显著低于对照组(P0.05);两组不良反应总发生率分别为5.88%、16.33%,组间比较差异无统计学意义(P0.05)。结论:丙泊酚用于急性颅脑手术患者具有较好的麻醉效果,能明显降低患者血清SOD、颅内压水平,减轻颅脑损伤。

Effects of Propofol on the Anesthesia, SOD and Intracranial Pressure in Patients with Craniocerebral Injury

ABSTRACT Objective: To study the effects of propofol on anesthesia, superoxide dismutase (SOD) and intracranial pressure in patients with craniocerebral injury. Methods: 100 patients with craniocerebral injury who admitted to our hospital from March 2017 to March 2019 were included in this study. According to the anesthesia method, they were divided into the observation group (n=51) and the control group (n=49). The control group was treated by isoflurane, while the observation group was treated by propofol. The respiratory recovery time, eye-opening time, extubation time, operative center rate, SOD, intracranial pressure, heart rate (HR), mean arterial pressure (MAP), visual analogue scale (VAS) score, simple intelligence scale (MMSE) level and adverse reactions were compared between the two groups. Results: The respiratory recovery time, eye opening time, extubation time and operative center rate of observation group were significantly shorter than those of the control group (P<0.05). At T0, there was no significant difference in SOD and intracranial pressure between the two groups. At T1 and T2, the level of SOD and intracranial pressure in both groups decreased compared with that at T0, and the SOD level in the observation group was significantly higher than that in the control group, and the intracranial pressure was lower than that in the control group (P<0.05). At T0, there was no significant difference in HR and MAP levels between the two groups. At T1 and T2, the HR and MAP levels in both groups were higher than those in T0, and the observation group was lower than the control group (P<0.05). There was no significant difference in VAS and MMSE scores between the two groups before operation. After operation, VAS and MMSE scores in the two groups decreased compared with those in T0, and MMSE scores in the observation group were significantly higher than those in the control group, while VAS scores were significantly lower than those in the control group (P<0.05). The total incidence of adverse reactions in the two groups was 5.88% and 16.33%, respectively, and no significant difference was found between the two groups(P>0.05). Conclusion: Propofol has a good anesthetic effect on patients with acute craniocerebral surgery, it can significantly reduce serum SOD and intracranial pressure, and craniocerebral injury.