308准分子激光联合他克莫司软膏治疗对白癜风患儿血清免疫球蛋白和IL-17、IL-22的影响

目的:探讨308准分子激光联合他克莫司软膏治疗儿童白癜风的疗效及对血清免疫球蛋白和白介素-17(IL-17)、白介素-22(IL-22)的影响。方法:选取2016年2月~2018年7月期间我院收治的127例白癜风患儿,根据随机数字表法将患儿分为对照组(n=63)和研究组(n=64),对照组患儿给予他克莫司软膏治疗,研究组在对照组的基础上给予308准分子激光治疗,比较两组患儿临床疗效、起效时间、免疫球蛋白、IL-17、IL-22水平,观察两组不良反应发生情况。结果:研究组患儿临床总有效率高于对照组,起效时间短于对照组(P<0.05)。两组患儿治疗后免疫球蛋白A(Ig A)、免疫球蛋白G(Ig G)、免疫球蛋白M(Ig M)均下降,且研究组低于对照组(P<0.05)。两组患儿治疗后血清IL-17、IL-22水平均下降,且研究组低于对照组(P<0.05)。两组不良反应发生率对比无统计学差异(P>0.05)。结论:308准分子激光联合他克莫司软膏治疗白癜风患儿疗效确切,可有效改善血清免疫球蛋白和IL-17、IL-22水平,具有一定的临床应用价值。

Effect of 308 Excimer Laser Combined with Tacrolimus Ointment on Serum Immunoglobulin, IL-17 and IL-22 in Children with Vitiligo

ABSTRACT Objective: To investigate the efficacy of 308 excimer laser combined with tacrolimus ointment in the treatment of vitiligo in children and its influence on serum immunoglobulin, interleukin-17 (IL-17) and interleukin-22 (IL-22). Methods: 127 children in vitiligo who were admitted to our hospital from February 2016 to July 2018 were selected, and they were divided into control group (n=63) and study group(n=64) according to random number table method. The control group was treated with tacrolimus ointment, and the study group was treated with 308 excimer laser on the basis of the control group. The clinical efficacy, onset time, immunoglobulin and the levels of IL-17 and IL-22 of the two groups were compared. The occurrence of adverse reactions in the two groups was observed. Results: The total clinical effective rate of the study group was higher than that of the control group, and the onset time was shorter than that of the control group (P<0.05). Immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) in the two groups decreased after treatment, and those in the study group were lower than those in the control group(P<0.05). The levels of serum interleukin-17(IL-17) and interleukin-22(IL-22) in the two groups decreased after treatment, and those in the study group were lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: 308 excimer laser combined with tacrolimus ointment in the treatment of children with vitiligo has a definite curative effect. It can effectively improve the levels of serum immunoglobulin, IL-17 and IL-22, and it has a certain clinical application value.