2型糖尿病合并肺部感染患者维生素D的表达及其临床意义

目的:研究2型糖尿病合并肺部感染患者维生素D的表达及其临床意义。方法:以2017年6月～2018年12月我院收治的2型糖尿病患者160例为研究对象。将所有患者按照是否发生肺部感染分为观察组(发生肺部感染)61例与对照组(未发生肺部感染)99例。分别比较两组患者基本资料、维生素D水平、血糖相关指标水平以及T淋巴细胞亚群相关指标,并分析2型糖尿病合并肺部感染患者维生素D与血糖指标、T淋巴细胞亚群相关指标的相关性。结果:两组患者年龄、性别以及糖尿病病程等基本资料对比差异均无统计学意义(均P0.05)。观察组患者空腹血糖、糖化血红蛋白水平高于对照组,而25(OH)D水平低于对照组,差异均有统计学意义(均P0.05)。观察组患者CD3~+、CD4~+以及CD4~+/CD8~+低于对照组,差异有统计学意义(均P0.05)。经Spearman相关性分析可得:25(OH)D与空腹血糖、糖化血红蛋白水平均呈负相关关系,而与CD3~+、CD4~+以及CD4~+/CD8~+均呈正相关关系(均P0.05)。结论:2型糖尿病合并肺部感染患者维生素D水平下降,通过检测维生素D水平,有助于评估患者的血糖水平与免疫功能状况。

Expression and Clinical Significance of Vitamin D in Type 2 Diabetes Mellitus Complicated with Pulmonary Infection

ABSTRACT Objective: To study the expression and clinical significance of vitamin D in patients with type 2 diabetes mellitus complicated with pulmonary infection. Methods:160 patients with type 2 diabetes mellitus who were treated in our hospital from June 2017 to December 2018 were selected as the research subjects. All patients were divided into observation group (with pulmonary infection) with 61 cases and control group (without pulmonary infection) with 99 cases according to whether they had pulmonary infection. The basic data, vitamin D level, blood glucose related indexes levels and T lymphocyte subsets related indexes levels of two groups were compared, and the correlation between vitamin D and blood glucose indexes, T lymphocyte subsets in patients with type 2 diabetes mellitus complicated with pulmonary infection were analyzed. Results: There was no significant difference in age, gender and duration of diabetes between the two groups (P>0.05). The levels of fasting blood glucose and glycated hemoglobin in the observation group were higher than that of the control group, but the level of 25(OH)D was lower than that of the control group, the difference was statistically significant (P<0.05). The levels of CD3⁺ , CD4⁺ and CD4⁺ /CD8⁺ in the observation group were lower than the control group, the difference was statistically significant (P<0.05). The Spearman correlation analysis showed that 25(OH)D was negatively correlated with fasting glucose and glycosylated hemoglobin, which was positively correlated with CD3⁺, CD4⁺ and CD4⁺/CD8⁺ (P<0.05). Conclusion: Vitamin D levels in patients with type 2 diabetes mellitus complicated with pulmonary infection are decreased. Detection of vitamin D level can help to assess the levels of blood glucose and immune function in patients.