个体动态化体重管理对体外受精-胚胎移植超重肥胖患者体重控制及妊娠结局的影响

目的:针对接受体外受精-胚胎移植(IVF-ET)的超重肥胖患者实施个体动态化体重管理,探讨该干预方法对体重控制及妊娠结局的影响。方法:选择2017年5月至2018年12月就诊于我院拟行IVF-ET的超重肥胖患者共99例纳入本研究,随机分为实验组50例与对照组49例,分别采取个体动态化体重管理及常规干预的方法对两组进行体重管理,记录并统计干预前后相关指标的组间差异。结果:两组干预前后BMI的差值差异有统计学意义(P0.05);内膜厚度、获卵数、可用胚胎数、移植胚胎数的组间比较差异无统计学意义(P0.05)。两组临床妊娠率与活产率差异有统计学意义(P0.05);出生婴儿体重组间差异无统计学意义(P0.05);干预满意度评分差异有统计学意义(P0.05)。结论:个体动态化体重管理的干预方法可有效减轻接受IVF-ET的超重肥胖患者的体重,降低体重指数,提高IVF-ET的移植成功率、活产率,值得临床推广应用。

Effect of Individual Dynamic Weight Management on Weight Control and Pregnancy Outcome in Overweight and Obese Patients Undergoing in Vitro Fertilization Embryo Transfer

ABSTRACT Objective: Individual dynamic weight management for overweight and obese patients undergoing in vitro fertilization embryo transfer (IVF-ET), to explore the effect of this intervention method on weight control and pregnancy outcome. Methods: From May 2017 to December 2018, a total of 99 overweight and obese patients who were hospitalized in our hospital for IVF-ET were randomly divided into experimental group (50 cases) and control group (49 cases). The methods of individual dynamic weight management and routine intervention were used to manage the weight of the two groups, and the differences of relevant indicators before and after the intervention were recorded and statistically analyzed. Results: The BMI D-value between the two groups before and after intervention was statistically significant (P<0.05), but no significant difference in intimal thickness, number of retrieved oocytes, available embryos and number of embryos transferred between the two groups (P>0.05). There was significant difference between the two groups in clinical pregnancy rate and live birth rate (P<0.05), but no significant difference in birth weight between the two groups (P>0.05), there was significant difference in intervention satisfaction score between the two groups(P<0.05). Conclusion: The intervention method of individual dynamic weight management can effectively reduce the weight of overweight and obese patients receiving IVF-ET, reduce body mass index, and improve the success rate and live rate of IVF-ET transplantation, which is worthy of clinical application.