慢性肾小球肾炎患者血清UA、Cys C、TAFI联合检测的临床意义

目的:探讨血清尿酸(UA)、胱抑素C(Cys C)和凝血酶激活纤溶抑制物(TAFI)联合检测在慢性肾小球肾炎(CGN)早期诊断中的应用价值。方法:选取2016年10月-2018年10月青海省人民医院肾内科收治的CGN患者80例作为研究组,同时间段于我院行体检的健康志愿者70例作为对照组,比较两组间UA、Cys C、TAFI和肾小球滤过率(GFR)的水平变化,采用Pearson相关性分析CGN患者GFR与UA、Cys C、TAFI的相关性,采用受试者工作特征(ROC)曲线比较各指标及联合检测对CGN的诊断价值。结果:与对照组相比,研究组血清UA、Cys C、TAFI水平均升高,GFR降低,差异有统计学意义(P<0.05);Pearson相关性分析显示,CGN患者GFR与UA、Cys C、TAFI呈显著负相关(P<0.05);联合检测血清UA、Cys C、TAFI水平,诊断CGN的敏感度为86.3%,特异性为80.0%,均明显高于UA、Cys C、TAFI的单独应用。结论:CGN患者血清UA、Cys C、TAFI水平升高,三者联合检测有助于临床早期诊断CGN。

Clinical Significance of Combined Detection of Serum UA, Cys- C and TAFI in Patients with Chronic Glomerulonephritis

ABSTRACT Objective: To analyze the value of combined detection of serum uric acid (UA), serum cystatin C (Cys C) and serum thrombin activated fibrinolytic inhibitor (TAFI) in the early diagnosis of chronic glomerulonephritis (CGN). Methods: 80 patients with CGN who were admitted to Nephrology Department of Qinghai People''s Hospital from October 2016 to October 2018 were selected as study group, and 70 cases of healthy patients (control group) who underwent physical examination in our hospital during the same period were selected as the research objects. The UA, Cys C, TAFI and glomerular filtration rate (GFR) levels between the two groups were compared. Pearson correlation analysis was used to analyze the correlation between GFR and UA, Cys C, TAFI. The diagnostic value of each index and combined detection for CGN was compared by receiver operating characteristics (ROC) curve. Results: Compared with the control group, the levels of UA, Cys C and TAFI in serum of the study group increased, while the levels of GFR decreased, the difference was statistically significant (P<0.05). Pearson correlation analysis showed that GFR was negatively correlated with UA, Cys C and TAFI in CGN patients (P<0.05). The sensitivity and specificity of combined detection of serum UA, Cys C and TAFI were 86.3% and 80.0% respectively, which were significantly higher than that of single application of UA, Cys C and TAFI. Conclusion: The levels of UA, Cys C and TAFI in serum of patients with CGN are increased. The combined detection of these three factors is helpful for the clinical early diagnosis of CGN.