脑小血管病患者血清尿酸水平和步态障碍之间的相关性

目的:探讨脑小血管病(Cerebral small vessel disease,CSVD)患者血清尿酸(Uric acid,UA)水平和步态障碍之间的相关性。方法:将我院自2018年1月至2019年1月收治的CSVD患者172例作为研究对象,根据患者血清尿酸水平分为研究组87例,对照组85例。收集和比较两组的临床资料,使用Logistic回归分析血清尿酸和CSVD患者脑室旁、深部白质高信号、步态障碍之间的相关性。结果:两组的年龄、性别、体质指数、血糖指标、血脂指标水平,合并高血压、糖尿病病史和吸烟情况比较差异无统计学意义(P0.05)。研究组血清尿酸水平、饮酒患者比例明显高于对照组(P0.05),脑室旁高信号和深部白质高信号中重度比例均明显高于对照组(P0.05);将步态障碍、脑室旁高信号与深部白质高信号作为影响因素带入相关分析,结果显示血清尿酸水平与步态障碍、脑室旁高信号与深部白质高信号比较存在正相关(P0.05)。结论:CSVD患者血清高尿酸水平与脑室旁、深部白质高信号病变程度呈明显的正相关性,也是患者步态障碍的影响因素。

Correlation between Serum Uric Acid Level and Gait Disturbance in Patients with Cerebrovascular Disease

ABSTRACT Objective: To investigate the correlation between serum uric acid (UA) level and gait disorders in patients with cerebellar small vessel disease (CSVD). Methods: 172 patients with CSVD admitted to our hospital from January 2018 to January 2019 were divided into the study group (87 cases) and the control group (85 cases) according to the serum uric acid level. The clinical data of the two groups were collected and compared, and Logistic regression analysis of the correlation between paraventricular, deep white matter high signal and gait disorder in patients with serum uric acid and CSBD. Results: There was no significant difference in age, sex, body mass index, blood glucose index, blood lipid index, hypertension, diabetes mellitus and smoking status between the two groups (P>0.05). The serum uric acid level and the proportion of drinking patients in the study group was significantly higher than that in the control group (P<0.05). The high ratio of ventricular high signal and deep white matter high signal were significantly higher than the control group (P<0.05). The gait disorder, high paraventricular signal and deep white matter high signal were taken as the influencing factors. The results showed that there was a positive correlation between serum uric acid level and gait disorder, high paraventricular signal and deep white matter high signal (P<0.05). Conclusion: The serum hyperuricemia of CSVD patients is positively correlated with the severity of high signal lesions in paraventricular and deep white matter, which is also a risk factor for gait disorder.