高血压人群中超敏C反应蛋白、尿酸及同型半胱氨酸水平与臂踝脉搏波传导速度关系的研究

目的:探讨高血压人群中超敏C反应蛋白(hs-CRP)、尿酸(UA)及同型半胱氨酸(Hcy)水平与臂踝脉搏波传导速度(bapwv)的关系。方法:选取2018年1月～2019年12月本院收治的78例高血压患者为研究对象,根据bapwv检测结果将患者分为bapwv正常组及bapwv升高组。采用单因素及多因素Logistic回归分析bapwv异常升高的影响因素。采用Pearson检验对hs-CRP、UA、Hcy与bapwv的相关性进行分析。结果:78例高血压患者中有41例出现bapwv异常升高,发生率为52.56%。经单因素分析显示,bapwv升高组与bapwv正常组患者在性别、年龄、体质指数(BMI)、吸烟史、饮酒史、高血压病程方面对比均无统计学差异(P0.05),bapwv升高组患者的收缩压(SBP)、舒张压(DBP)、hs-CRP、UA、Hcy水平均高于bapwv正常组患者(P0.05)。经多因素Logistic回归分析显示,SBP、DBP、hs-CRP、UA、Hcy均是bapwv异常升高的独立危险因素(OR=1.309、1.193、1.416、1.309、1.205,P0.05)。经Pearson相关分析显示,高血压人群的hs-CRP、UA、Hcy均与bapwv呈正相关(r=0.488、0.510、0.493,P0.05)。结论:hs-CRP、UA、Hcy均是高血压人群bapwv异常升高的独立危险因素,并均与bapwv呈正相关。

Study on the Relationship between the Levels of High-sensitivity C-reactive Protein, Uric Acid and Homocysteine and Brachial Ankle Pulse Wave Conduction Velocity in Hypertension

ABSTRACT Objective: To investigate the relationship between the levels of high sensitive C-reactive protein (hs-CRP), uric acid (UA) and homocysteine (Hcy) and brachial ankle pulse wave velocity (bapwv) in hypertension. Methods: 78 patients with hypertension who were admitted to our hospital from January 2018 to December 2019 were selected as the study objects. According to the results of bapwv test, the patients were divided into bapwv normal group and bapwv increased group. The influencing factors of abnormal increase of bapwv were analyzed by single factor and multi factor Logistic regression. The correlation between hs-CRP, UA, Hcy and bapwv were analyzed by pearson test. Results: 41 out of 78 patients with hypertension had abnormal increase of bapwv, the incidence was 52.56%. Single factor analysis showed that there were no significant difference in gender, age, body mass index (BMI), smoking history, drinking history and the course of hypertension between bapwv increased group and bapwv normal group (P>0.05). Systolic blood pressure (SBP), diastolic pressure (DBP), hs-CRP, UA and Hcy in bapwv increased group were higher than those in bapwv normal group (P<0.05). The multivariate logistic regression analysis showed that SBP, DBP, hs-CRP, UA, Hcy were all independent risk factors for the abnormal increase of bapwv (OR=1.309, 1.193, 1.416, 1.309, 1.205, P<0.05). Pearson test showed that hs-CRP, UA and Hcy were positively correlated with bapwv (r=0.488, 0.510, 0.493, P<0.05). Conclusion: hs-CRP, UA and Hcy are the independent risk factors for the abnormal increase of bapwv in hypertension, and they are all positively correlated with bapwv.