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Antiinflammatory 4,5-diarylimidazoles as selective cyclooxygenase inhibitors |
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| Authors: | Thomas E Barta Michael A Stealey Paul W Collins Richard M Weier |
| Institution: | G.D. Searle an dCo., 4901 Searle Parkway, Skokie, IL 60077, U.S.A. |
| Abstract: | The synthesis and activity of a series of 4,5-diarylimidazole analogs are described. One analog had an IC50 of 80 nM, was 6750-selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model. |
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