Convenient synthesis of human calcitonin and its methionine sulfoxide derivative |
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Authors: | Shi Tiesheng Rabenstein Dallas L |
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Affiliation: | Department of Chemistry, University of California, Riverside, CA 92521, USA. |
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Abstract: | The human calcitonin peptide chain was assembled using Fmoc solid-phase peptide synthesis chemistry. The combinations of cleavage Reagent H with trans-[Pt(en)(2)Cl(2)](2+) and Reagents B, K, and R with trans-[Pt(CN)(4)Cl(2)](2-) provide convenient methods for the synthesis of human calcitonin and its methionine sulfoxide derivative; the formation of intramolecular disulfide bonds by the above Pt(IV) oxidants is essentially quantitative. |
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