Density-dependent nerve growth factor regulation of Gs-alpha RNA in pheochromocytoma 12 cells. |
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| Authors: | G Tjaden A Aguanno R Kumar D Benincasa R M Gubits H Yu K P Dolan |
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| Affiliation: | Department of Biology, New York University, New York 10003. |
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| Abstract: | Nerve growth factor (NGF) affects levels of the alpha subunit of the stimulatory G protein (Gs-alpha) in pheochromocytoma 12 cells in a bidirectional, density-dependent manner. Cells grown at high density responded to NGF treatment with increased levels of Gs-alpha mRNA and protein. Conversely, in cells grown in low-density cultures, levels of this mRNA were lowered by NGF treatment. |
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