Dispensable role of PTEN in mouse spermatogenesis |
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Authors: | Huang Yue Mao Xia Boyce Terry Zhu Guo-Zhang |
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Affiliation: | Department of Biology, Marshall University, Huntington, WV 25755, USA. |
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Abstract: | PTEN (phosphatase and tensin homologue deleted on chromosome ten) plays critical roles in multiple cellular processes, including cell proliferation, survival, migration and transformation. A role of PTEN in mammalian spermatogenesis, however, has not been explored. To address this question, we generated a mouse model with PTEN conditional knockout in postnatal male germ cells. We found that spermatogenesis was normal in PTEN-deleted male germ cells. PTEN conditional mutant males produced sperm and sired offspring as competently as wild-type littermates. Moreover, our biochemical analysis also indicated that the Akt (acutely transforming retrovirus AKT8 in rodent T cell lymphoma) signalling pathway was not affected in mutant testis. Taken together, these findings demonstrate that PTEN is dispensable in mouse spermatogenesis. |
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Keywords: | Akt conditional knockout male germ cell PTEN spermatogenesis |
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