The effect of low levels of carbon dioxide on metabolism of Mus musculus |
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| Affiliation: | 1. First Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece;2. Fourth Department of Surgery, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece;3. Surgical Department, General Hospital of Ierapetra, Ierapetra, Greece;4. First Department of Propaedeutic Surgery, National and Kapodistrian University of Athens, Hippocration Hospital, Athens, Greece |
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| Abstract: | - 1.1. In this study we measured the metabolic response of individual mice to low concentrations of carbon dioxide in air (0.14 to 1.7%). Both oxygen consumption (Vo2) and carbon dioxide (Vo2) were determined, and the respiratory quotient (R) was calculated.
- 2.2. Vo2 was significantly reduced at levels of 0.14 to 0.50% CO2 in the air. At 0.23% for example, Vo2 dropped from 3.11 ± 0.6 to 1.26 ± 0.69 cc O2/g × hr. R increased from 0.7 to 1.0 and higher throughout the 6-hr testing period, which consisted of 1.5 hr of exposure to 0.0% CO2, 1.5 hr of exposure to a test gas and a repetition of 1.5 hr each of baseline and test exposures.
- 3.3. We conclude that low levels of CO2 such as mice might encounter in a nest, burrow or even metabolic chamber may effect a feedback mechanism which acts to decrease metabolism.
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