Reduced high affinity cholecystokinin binding in hippocampus and frontal cortex of schizophrenic patients |
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Authors: | S M Farmery F Owen M Poulter T J Crow |
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Institution: | Division of Psychiatry, MRC Clinical Research Centre, Watford Road, Harrow, HA1 3UJ, U.K. |
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Abstract: | Cholecystokinin (CCK) binding sites were assessed in post-mortem brain membrane preparations from controls and schizophrenic patients. 125I-BH CCK33 specific binding was reduced by 40% (p less than 0.02) in the hippocampus and by 20% (p less than 0.01) in the frontal cortex of schizophrenic patients compared with controls. There were no differences in 125I-BH CCK33 binding between the two groups in the amygdala, temporal cortex or caudate nucleus. |
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