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Synthesis of cationic beta-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1 |
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| Authors: | Silva Eduarda M P Giuntini Francesca Faustino Maria A F Tomé João P C Neves Maria G P M S Tomé Augusto C Silva Artur M S Santana-Marques Maria G Ferrer-Correia António J Cavaleiro José A S Caeiro Maria F Duarte Ricardo R Tavares Sabina A P Pegado Inês N d'Almeida Bruno De Matos António P A Valdeira Maria L |
| Institution: | Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. |
| Abstract: | An easy route to cationic beta-vinyl substituted meso-tetraphenylporphyrin derivatives is described. Two novel compounds were tested in vitro for their antiviral photoactivity against herpes simplex virus type 1. One of these compounds exhibited a significant activity, reaching 99% of virus inactivation after 15 min of photoactivation. |
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