Glucocorticoids increase beta-adrenoceptors on human intact lymphocytes in vitro |
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Authors: | S Cotecchia A De Blasi |
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Affiliation: | Istituto di Ricerche Farmacologie “Mario Negri” Via Eritrea, 62 - 20157 Milan, Italy |
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Abstract: | A modification of beta-adrenoceptor binding has been observed in different human and animal tissues after glucocorticoid administration. In this study we observed that hydrocortisone increased human intact lymphocyte beta-adrenoceptors labelled with 3H-dyhydroalprenolol in vitro, in physiological and pharmacological concentrations. In saturation experiments hydrocortisone (10(-6)M) significantly raised beta-adrenoceptor Bmax and KD. Intact living lymphocytes seem to be a useful model for further investigation in man of the regulation of beta-adrenoceptors by glucocorticoids in physiological conditions. |
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