A computational model of how an interaction between the thalamocortical and thalamic reticular neurons transforms the low-frequency oscillations of the globus pallidus |
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Authors: | Arash Hadipour-Niktarash |
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Institution: | (1) Department of Biomedical Engineering, Laboratory for Computational Motor Control, Johns Hopkins School of Medicine, 720 Rutland Ave, 416, Traylor Building, Baltimore, MD 21205-2195, USA;(2) Institute for Studies in Theoretical Physics and Mathematics (IPM), School of Cognitive Sciences, Tehran, Iran |
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Abstract: | In Parkinson’s disease, neurons of the internal segment of the globus pallidus (GPi) display the low-frequency tremor-related
oscillations. These oscillatory activities are transmitted to the thalamic relay nuclei. Computer models of the interacting
thalamocortical (TC) and thalamic reticular (RE) neurons were used to explore how the TC-RE network processes the low-frequency
oscillations of the GPi neurons. The simulation results show that, by an interaction between the TC and RE neurons, the TC-RE
network transforms a low-frequency oscillatory activity of the GPi neurons to a higher frequency of oscillatory activity of
the TC neurons (the superharmonic frequency transformation). In addition to the interaction between the TC and RE neurons,
the low-threshold calcium current in the RE and TC neurons and the hyperpolarization-activated cation current (I h) in the TC neurons have significant roles in the superharmonic frequency transformation property of the TC-RE network. The
external globus pallidus (GPe) oscillatory activity, which is directly transmitted to the RE nucleus also displays a significant
modulatory effect on the superharmonic frequency transformation property of the TC-RE network.
Action Editor: John Rinzel |
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Keywords: | Thalamus Basal ganglia Globus pallidus Oscillations Computational models Frequency transformation Parkinson’ s disease |
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