UV-induced mutability in repair-deficientrad6-1 strains ofSaccharomyces cerevisiae is caused by a suppressor gene |
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| Authors: | V Vl?ková Z ?uffová J Brozmanová |
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| Institution: | (1) Department of Genetics and Molecular Biology, Faculty of Science, Comenius University, 842 15 Bratislava, Czechoslovakia;(2) Department of Molecular Genetics, Cancer Research Institute, Slovak Academy of Sciences, 812 32 Bratislava, Czechoslovakia |
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| Abstract: | TheRAD6 gene is a multifunctional gene required for DNA repair, induced mutagenesis and sporulation. The survival and revertibility
of two loci in fourrad6-1 mutant strains of different origin after UV irradiation were followed. As expected, all therad6-1 strains tested were more sensitive to UV radiation in comparison withRAD6 strains. The reversion frequency per survivor intrpl-289 andarg4–17 alleles was significantly higher in all fourrad6-1 mutant strains than in wild-type strains after equal doses of UV radiation. On the basis of genetic analysis we suggest that
the phenomenon of increased frequency of induced mutagenesis is caused by a suppressor gene. |
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