Ceruloplasmin serum level in post-menopausal women treated with oral estrogens administered at different times. |
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Authors: | C Clemente F Russo M G Caruso M Giangrande G Fanizza A Di Leo |
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Institution: | Laboratorio di Biochimica, I.R.C.C.S.S. de Bellis Castellana G., Bari, Italy. |
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Abstract: | The liver is an estrogen-responsive organ and the administration of estrogens in humans increases the hepatic synthesis of many proteins. The existence of a circadian rhythm of estrogen receptors in the liver has been proved by different authors. We studied the presence of a different responsiveness of the human liver to the estrogens in two groups of post-menopausal women by evaluating the changes in ceruloplasmin serum level. Conjugated equine estrogens were administered at different times (A: 8 a.m. and B: 8 p.m.). The replacement therapy increased ceruloplasmin serum levels both in group A and B, but the increase was higher in group B than in group A. These data reflect indirectly the presence of a circadian rhythm of hepatic responsiveness to the estrogens. |
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