Computer programs for single channel kinetic analysis

Programs are represented that permit us to solve the following three problems of single channel kinetic activity: 1) to fulfill a preliminary analysis of single channel activity, i.e., to estimate the minimum number of agonist molecules that bind with a channel structure, the minimum number of open and closed kinetic states of the channel, and possible connections between these states, to check the condition of thermodynamic equilibrium and adequacy of a Markovian assumption for modeling of the channel kinetics; 2) to select the model of channel gating: for a given number of kinetic states, the potential models that permit us to fit a list of dwell-times observed in an experiment are examined; the model is selected by a criterium of the maximum likelihood; 3) to simulate the response to a rapid change of the agonist concentration of single channels that demonstrate processes of adaptation or inactivation.