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Inhibitory influences of MIF-1 (PLG) and Tyr-MIF-1 (YPLG) on aggression and defeat-induced analgesia in mice |
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| Authors: | Martin Kavaliers and Maurice Hirst |
| Institution: | a Division of Oral Biology, Faculty of Dentistry, The University of Western Ontario, London, Ontario, Canada N6A 5C1 b Department of Pharmacology and Toxicology The University of Western Ontario, London, Ontario, Canada N6A 5C1 |
| Abstract: | The effects of prolyl-leucyl-glycinamide (MIF-1, PLG), tyrosine-prolyl-leucyl-glycinamide (Tyr-MIF-1, YPLG) and the exogenous opiate antagonist, naloxone, on aggressive interactions and defeat-induced analgesia were examined in male mice. All three substances reduced the number of bites required to obtain defeat in subordinate mice during aggressive encounters, as well as blocking subsequent defeat-induced analgesia. Tyr-MIF-1 had significantly greater inhibitory effects than MIF. These results suggest that both MIF and Tyr-MIF-1 may function as endogenous opioid antagonists and have inhibitory influences on aggression, with the antagonistic effects of Tyr-MIF-1 being more potent than those of MIF-1. |
| Keywords: | Stress-induced analgesia Endogenous opioid Aggression Naloxone Social conflict Prolyl-leucyl-glycinamide PLG MIF-1 Tyrosine-prolyl-leucyl-glycinamide YPLG Tyr-MIF-1 |
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