Chemical modifications of transfer RNA species. Metal ion binding to monoperphthalate-treated tRNA |
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| Authors: | S M Hecht R M Bock |
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| Affiliation: | 1. Department of Food Quality and Safety, Volcani Center, Agricultural Research Organization, Bet Dagan 50250, Israel;2. The Dead Sea & Arava Science Center and Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev, Beer-Sheba, 84105, Israel;3. School of Chemistry, Tel Aviv University, Ramat Aviv 69978, Israel;1. Biophysical Chemistry Laboratory, Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700 032, India;2. Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700 032, India;1. Institute of Cellular Biology and Neurobiology, National Research Council, Rome, Italy;2. Center for Alcohol Abuse (Centro Riferimento Alcologico Regione Lazio-CRARL), Department of Clinical Medicine, University La Sapienza, Rome, Italy;3. Division of Cell Biology, Medical University, Varna, Bulgaria;4. Division of Child Neurology, Department of Pediatrics, University La Sapienza, Rome, Italy |
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| Abstract: | Oxidation of the “exposed” adenosine moieties in intact tRNA's enhances the binding of heavy metal ions to the tRNA's. Experiments utilizing copper, cadmium and samarium ions indicated that binding enhancement was directly proportional to the degree of oxidation. |
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