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Plasmid rolling circle replication and its control |
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| Authors: | Manuel Espinosa Gloria del Solar Fernando Rojo Juan C. Alonso |
| Affiliation: | Centro de Investigations Biológicas, CSIC, Velázquez 144, 28006 Madrid, Spain; Centro National de Biotecnología, CSIC, Campus Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain |
| Abstract: | Abstract This review summarises current information on rolling circle replicating plasmids originally isolated from Gram-positive bacteria with a low guanine and cytosine content in their DNA. It focuses on the peculiar biological features of these small, high copy number plasmids that replicate via an asymmetric RC mechanism. The regulation of plasmid copy number is also discussed. |
| Keywords: | Replication origin Initiation-termination protein Plasmid copy control Antisense RNA |