NAD/NADP及其介导氧化应激在神经退行性疾病中的作用

神经退行性疾病如阿尔茨海默病、帕金森病、亨廷顿病等疾病的发生与氧化应激紧密相关。NAD和NADP是维持氧化系统和抗氧化系统平衡的两个关键物质。NAD和NADP的生物合成和降解有多种途径,参与其生物途径的物质如NAMPT、NADK、PARP1、SIRT1、CD38等,均报道在神经退行性疾病发挥一定的作用。因此,本文分别从NAD和NADP的合成和降解途径中的一些关键物质出发,结合氧化应激总结并探讨它们在神经退行性疾病的作用,以期为临床治疗神经退行性疾病提供新思路。

NAD/NADP and the Role in Neurodegenerative Diseases by Mediating Oxidative Stress

ABSTRACT: Neurodegenerative diseases such as Alzheimer''s disease, Parkinson''s disease, Huntington''s disease and other diseases are closely related to oxidative stress. NAD and NADP are two key substances that maintain the balance between the oxidation system and the antioxidant system. NAD and NADP biosynthesis and degradation have a variety of ways, some moleculars to participate in their biological pathways such as NAMPT, NADK, PARP1, SIRT1, CD38, etc, are reported in neurodegenerative diseases playing a role. Therefore, this article sum up and explore their roles in neurodegenerative diseases from the point of some key substances in NAD and NADP synthesis and degradation combined with oxidative stress, with a view to provide new ideas for clinical treatment of neurodegenerative diseases.