涤毒灌肠方对慢性肾衰竭患者肠源性尿毒症毒素的影响分析

目的:探讨涤毒灌肠方对慢性肾衰竭患者肠源性尿毒症毒素的影响。方法:选择2014年2月到2017年6月在我院肾病科门诊及住院诊治的慢性肾衰竭患者92例,按患者意愿分为研究组与对照组各46例。对照组给予常规治疗措施,研究组在对照组治疗的基础上给予涤毒灌肠方治疗,两组都治疗3个月。记录两组疗效、治疗前后肾功能的变化与肠源性尿毒症毒素的释放情况。结果:治疗后,研究组与对照组的总有效率分别为93.5%和78.3%,研究组显著高于对照组(P0.05)。两组治疗后的血肌酐与尿素氮水平都显著低于治疗前(P0.05),且研究组显著低于对照组(P0.05)。研究组治疗后的大肠杆菌、肠球菌值均显著低于对照组(P0.05),双歧杆菌、乳酸杆菌值均显著高于对照组(P0.05)。研究组与对照组治疗后的内毒素含量为0.026±0.004 EU/mL和0.030±0.006 EU/mL,研究组显著低于治疗前的,且显著低于对照组(P0.05)。结论:涤毒灌肠方用于慢性肾衰竭患者中的辅助治疗能抑制肠源性尿毒症毒素的释放,改善肠道菌群及肾功能,提高治疗效果。

Analysis of the Effects of Ditan Enema on the Enteric Uremic Toxin in Patients with Chronic Renal Failure

ABSTRACT Objective: To explore the effects of Ditan enema on the enteric uremic toxin in patients with chronic renal failure. Methods: 92 cases of patients with chronic renal failure in the department of nephropathy of our hospital from February 2014 to June 2017 were selected as the research object. All the patients were randomly divided into the study group and the control group with 46 patients in each group. The control group was given routine treatment measures, the study group was treated with dydic enema on the basis of treatment in the control group, and both groups were treated for 3 months. The prognosis, renal function and release of enteric uremic toxin were compared between two groups. Results: The total effective rate of study group and control group were 93.5% and 78.3%, which was significantly higher in the study group than that of the control group(P<0.05). After treatment, the levels of serum creatinine and urea nitrogen were significantly lower in the two groups than before the treatment (P<0.05), which were significantly lower in the study group than those of the control group after treatment(P<0.05). After treatment, the levels of E. coli and enterococci in the study group were lower than those in the control group, and the values of Bifidobacterium and lactobacillus were higher than those in the control group(P<0.05). After treatment, the endotoxin content in the study group and the control group were 0.026±0.004 EU/mL and 0.030±0.006 EU/mL, which was significantly lower in the study group than that before treatment and that in the control group(P<0.05). Conclusion: The auxiliary application of Ditan enema can inhibit the release of enteral uremic toxin, improve the intestinal flora level, promote the improvement of renal function and improve the therapeutic effect in the treatment of patients with chronic renal failure.