Erythrocyte Oxidant/Antioxidant Status in Essential Hyperhidrosis |
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Authors: | Semsettin Karaca Mustafa Kulac Efkan Uz Hakan Mollaoglu H. Ramazan Yilmaz |
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Affiliation: | (1) Department of Dermatology, School of Medicine, Kocatepe University, Afyonkarahisar, Turkey;(2) Department of Medical Biology and Genetics, School of Medicine, Suleyman Demirel University, Isparta, Turkey;(3) Department of Physiology, School of Medicine, Kocatepe University, Afyonkarahisar, Turkey;(4) School of Medicine, Kocatepe University, Afyonkarahisar, Turkey;(5) Ahmet Necdet Sezer Uygulama ve Arastyrma Hastanesi, Dermatoloji Klinigi (Pembe Hastane), Kocatepe Universitesi, Afyonkarahisar, Turkey |
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Abstract: | Essential Hyperhidrosis is a disorder of excessive, bilateral, and relatively symmetric sweating occurring in the axillae, palms, soles, or craniofacial region without obvious etiology. Nitric oxide may play a physiological part in the production and/or excretion of sweat in skin eccrine glands. Tempol, a SOD mimetic, increases the half-life of NO and results in vasodilatation, hypotension, and reflex activation of sympathetic nervous system. Reactive oxygen species (ROS) may directly activate both central and peripheral sympathetic nervous system activity. We assessed the levels of malondialdehyde (MDA), the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) of red blood cells in patients with essential hyperhidrosis (n = 31) compared to age-and sex-matched healthy controls (n = 28). Erythrocyte activities of SOD and level of MDA were detected significantly higher (p = 0.020, p = 0.004 and respectively) and activities of CAT and GSH-Px were significantly lower (p = 0.0001, p = 0.0001 respectively) in patients than controls. Our results support the hypothesis that oxidative damage resulting from increased ROS production along with insufficient capacity of antioxidant mechanisms may be involved in pathogenesis of EH. |
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Keywords: | essential hyperhidrosis catalase superoxide dismutase glutathione peroxidase malondialdehyde |
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