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Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis
Authors:Joan Sanchez-Gurmaches  Yuefeng Tang  Naja Zenius Jespersen  Martina Wallace  Camila Martinez Calejman  Sharvari Gujja  Huawei Li  Yvonne J.K. Edwards  Christian Wolfrum  Christian M. Metallo  Søren Nielsen  Camilla Scheele  David A. Guertin
Affiliation:1. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA;2. The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark;3. Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, 2200 Copenhagen, Denmark;4. Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA;5. Institute of Food, Nutrition and Health, ETH-Zürich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
Abstract:
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  • Keywords:UCP1  white fat  thermogenesis  lipid metabolism  lipid synthesis  SREBP  Akt  insulin signalling  obesity
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