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Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis
Authors:Yutaka Hasegawa  Kenji Ikeda  Yong Chen  Diana L. Alba  Daniel Stifler  Kosaku Shinoda  Takashi Hosono  Pema Maretich  Yangyu Yang  Yasushi Ishigaki  Jingyi Chi  Paul Cohen  Suneil K. Koliwad  Shingo Kajimura
Affiliation:1. UCSF Diabetes Center, San Francisco, CA, USA;2. Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA, USA;3. Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA;4. Department of Medicine, University of California, San Francisco, San Francisco, CA, USA;5. The Rockefeller University, Laboratory of Molecular Metabolism, New York, NY, USA;6. Division of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University, Morioka, Uchimaru, Japan;7. Department of Chemistry and Life Science, College of Bioresource Sciences, Nihon University, Tokyo, Japan
Abstract:
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  • Keywords:obesity  diabetes  brown adipose tissue  beige adipocyte  adipose tissue fibrosis  PRDM16  EHMT1  GTF2IRD1  UCP1-independent  insulin resistance
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