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Lysosomal tartrate sensitive acid phosphatase deficiency in cells which contain lysosomal "high uptake forms"
Authors:P Hu  G Parenti  J Keulemans  A T Hoogeveen
Institution:Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands.
Abstract:The catalytic and immunological properties of acid phosphatases (EC 3.1.3.2.) in different tissues were studied. It was demonstrated that high uptake forms of lysosomal enzymes like beta-galactosidase isolated from human platelets and bovine testis are mature enzymes, which have not lost their mannose-6phosphate marker. The results presented indicate that this phenomenon is related to a low activity or the complete absence of the lysosomal tartrate sensitive acid phosphatase activity in the tissues concerned.
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