真菌双组分信号转导系统及其抑制剂研究进展

双组分信号转导系统存在于包括真菌在内的大部分低等真核生物、原核生物及一些植物中。真菌双组分信号转导蛋白在细胞新陈代谢、毒力以及致病性等方面具有重要作用,且目前在人类细胞中尚未发现双组分信号转导系统。因此,探明真菌双组分信号转导系统的机制,可为抑制剂的设计和寻找提供多个"靶点",从而研制出能够抗致病性真菌而不对宿主细胞造成损伤的新型抗真菌药物。本文就近年来真菌双组分信号转导系统及其潜在抑制剂进行综述。

Progression on the research of two-component signal transduction system in fungus and its inhibitors

Two-component signal transduction system,which plays an important role in cell metabolism,virulence and pathogenicity,has been found in most lower eukaryotes,prokaryotes and some plants,yet not in human cells.Well-understanding of the mechanism may be helpful for inhibitor designing,which has antifungal effect without damage to host cell.Recent literatures about two-component signal transduction system in fungi and potential inhibitors are reviewed.