Localisation of [3H] clonidine binding in rat neurohypophysis by means of electron-microscopic autoradiography期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Localisation of [3H] clonidine binding in rat neurohypophysis by means of electron-microscopic autoradiography

Authors:	Dr. A. Livingston B. Morris

Affiliation:	(1) Department of Pharmacology, Medical School, University of Bristol, Bristol, UK;(2) Department of Pharmacology, Medical School, BS8 1TD Bristol, UK;(3) Present address: Lab. Neuropharmakologie, Max-Planck Institut für Psychiatrie, D-8033 Planegg/Martinsried, Germany

Abstract:	Summary Electron-microscopic autoradiography of rat neurohypophyses treated with [³H] clonidine, an ₂-agonist, showed that binding apparently occurred preferentially at the neurosecretory endings and blood vessels rather than on the pituicytes. Since it is known that clonidine has a high affinity for plasma proteins, the distribution over the neurosecretory nerve endings would suggest the existence of presynaptic ₂-binding sites on neurosecretory neurones, which could indicate a regulatory function for catecholamines in neurohypophysial hormone release.

Keywords:	Pituitary gland, posterior lobe Electron-microscopic autoradiography /content/um511712h1003643/xxlarge945.gif" alt=" agr" align=" BASELINE" BORDER=" 0" >₂-Binding sites Clonidine Rat
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