Localisation of [3H] clonidine binding in rat neurohypophysis by means of electron-microscopic autoradiography |
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Authors: | Dr A Livingston B Morris |
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Institution: | (1) Department of Pharmacology, Medical School, University of Bristol, Bristol, UK;(2) Department of Pharmacology, Medical School, BS8 1TD Bristol, UK;(3) Present address: Lab. Neuropharmakologie, Max-Planck Institut für Psychiatrie, D-8033 Planegg/Martinsried, Germany |
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Abstract: | Summary Electron-microscopic autoradiography of rat neurohypophyses treated with 3H] clonidine, an 2-agonist, showed that binding apparently occurred preferentially at the neurosecretory endings and blood vessels rather than on the pituicytes. Since it is known that clonidine has a high affinity for plasma proteins, the distribution over the neurosecretory nerve endings would suggest the existence of presynaptic 2-binding sites on neurosecretory neurones, which could indicate a regulatory function for catecholamines in neurohypophysial hormone release. |
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Keywords: | Pituitary gland posterior lobe Electron-microscopic autoradiography 2-Binding sites" target="_blank">gif" alt="agr" align="BASELINE" BORDER="0">2-Binding sites Clonidine Rat |
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