Long non-coding RNA-422 acts as a tumor suppressor in colorectal cancer |
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| Authors: | Qianwen Shao Jing Xu Rong Deng Wei Wei Bing Zhou Chao Yue Miaoling Zhu Xingen Huang Haitao Zhu |
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| Institution: | 1. Department of Oncology, Jiangsu Province Hospital, The first Affiliated Hospital of Nanjing Medical University, Nanjing 210009, Jiangsu Province, PR China;2. Genetic Testing Center, Department of Oncology of the First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, Jiangsu Province, PR China;3. Colorectal Cancer Center, Department of General Surgery, Jiangsu Cancer Hospital, Cancer Research Institute, Cancer hospital of Nanjing Medical University, Nanjing 210009, Jiangsu Province, PR China;4. Department of Pathology, Cancer Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, PR China;5. Department of Medical, Cancer Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, PR China |
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| Abstract: | Colorectal cancer (CRC) is one of the most frequent cancer in numerous of countries worldwidely. The initiation and progression of CRC is an extremely complex process, and have been suggested a correlation with Long non-coding RNAs (lncRNAs). Our results showed that lncRNA-422(ENST00000415820) significantly downregulated in the tissues and serum of CRC patients, and is closely associated with the poor prognosis. Then gain or loss of lncRNA-422 models in SW480 and SW620cells were established. The results showed that lncRNA-422 overexpression inhibited cell proliferation, migration, and invasion. Knockdown of lncRNA-422 promoted tumorigensis. Western blot and qRT-PCR were performed to examine the activity of the PI3K/AKT/mTOR pathway in CRC cells after alternation of lncRNA-422. Results showed that lncRNA-422 acts as a tumor suppressor by PI3K/AKT/mTOR pathway in CRC. |
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| Keywords: | lncRNA-422 Colorectal cancer Proliferation Apoptosis PI3K/AKT/mTOR |
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