Direct regulation of IL-2 by curcumin |
| |
Authors: | Jin-Gyo Oh Da-Jeong Hwang Tae-Hwe Heo |
| |
Institution: | 1. Lab of Pharmaco-Immunology, Integrated Research Institute of Pharmaceutical Sciences, BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future Pharmacy, College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Republic of Korea;2. ILAb Inc., NP513, College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Republic of Korea |
| |
Abstract: | Interleukin-2 (IL-2) is a crucial growth factor for both regulatory and effector T cells. Thus, IL-2 plays a critical role in the stimulation and suppression of immune responses. Recently, anti-IL-2 antibodies (Abs) have been shown to possess strong IL-2 modulatory activities by affecting the interaction between IL-2 and IL-2 receptors. In this study, we screened an herbal library to identify a compound that regulates IL-2, which resulted in the identification of curcumin as a direct binder and inhibitor of IL-2. Curcumin is a phytochemical with well-known anti-cancer properties. In this study, curcumin mimicked or altered the binding pattern of anti-IL-2 Abs against IL-2 and remarkably inhibited the interaction of recombinant IL-2 with the IL-2 receptor α, CD25. Interestingly, curcumin neutralized the biological activities of IL-2 both in vitro and in vivo. In this report, we elucidated the unsolved mechanism of the anti-cancer effect of curcumin by identifying IL-2 as a direct molecular target. Curcumin, as a small molecule IL-2 modulator, has the potential to be used to treat IL-2 related pathologic conditions. |
| |
Keywords: | Interleukin-2 (IL-2) Interleukin-2 receptor alpha (IL-2Rα) Vascular leak syndrome (VLS) Surface plasmon resonance (SPR) Curcumin |
本文献已被 ScienceDirect 等数据库收录! |
|