Synthesis of Pyridyl-4-Oxy-Substituted N-Hydroxy Amides of Cinnamic Acid as New Inhibitors of Histone Deacetylase Activity and Hepatitis C Virus Replication |
| |
| Authors: | M. V. Kozlov A. Z. Malikova K. A. Kamarova K. A. Konduktorov S. N. Kochetkov |
| |
| Affiliation: | 1.Engelhardt Institute of Molecular Biology,Russian Academy of Sciences,Moscow,Russia |
| |
| Abstract: | Three structural isomers of pyridyl-4-oxy-substituted N-hydroxy amides of cinnamic acid (PyOCHA) have been synthesized for the first time. The relationship between their antiviral activity against hepatitis C virus (HCV) and inhibition of histone deacetylases of different cellular localization has been studied. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
