Synthesis of Pyridyl-4-Oxy-Substituted <Emphasis Type="Italic">N</Emphasis>-Hydroxy Amides of Cinnamic Acid as New Inhibitors of Histone Deacetylase Activity and Hepatitis C Virus Replication |
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| Authors: | M V Kozlov A Z Malikova K A Kamarova K A Konduktorov S N Kochetkov |
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| Institution: | 1.Engelhardt Institute of Molecular Biology,Russian Academy of Sciences,Moscow,Russia |
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| Abstract: | Three structural isomers of pyridyl-4-oxy-substituted N-hydroxy amides of cinnamic acid (PyOCHA) have been synthesized for the first time. The relationship between their antiviral activity against hepatitis C virus (HCV) and inhibition of histone deacetylases of different cellular localization has been studied. |
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