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Unscheduled DNA synthesis in primary cultures of human placentae. |
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| Authors: | D M Lefkowitz R C Johnson W P Faulk R A Vincent |
| Institution: | 1. Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina, Charleston, SC 29403, USA;2. Department of Pathology, Medical University of South Carolina, Charleston, SC 29403, USA |
| Abstract: | Ultraviolet light-induced unscheduled DNA synthesis in primary cultures of human placentae examined as a function of radiation-dose and repair-incubation period was found to be dependent upon cell type and independent of gestational age. Primary cultures obtained by continuous harvesting of enzymatically released cells from fragments of 11-week and term specimens contained cytotrophoblasts and fibroblasts. Fibroblasts exhibited 3-fold more repair than did cytotrophoblasts from the same organ at both 11 weeks and term. |
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