Comparison of optimization methods for fed-batch cultures of hybridoma cells |
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Authors: | J. A. Roubos C. D. de Gooijer G. van Straten A. J. B. van Boxtel |
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Affiliation: | Wageningen Agricultural University, Department of Agricultural Engineering and Physics, Bomenweg 4, 6703 HD Wageningen, the Netherlands, NL
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Abstract: | Two methods for the calculation of optimal trajectories for the input variables of a fed-batch culture of hybridoma cells are compared. It pointed out that a gradient method based on Pontryagins' minimum principle based yields a significant better performance with respect to computational effort and the calculated minimum than a dynamic programming approach which has been presented in a previous paper [1] as the most suitable method. |
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