MACAT--microarray chromosome analysis tool |
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| Authors: | Toedling Joern Schmeier Sebastian Heinig Matthias Georgi Benjamin Roepcke Stefan |
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| Institution: | Freie Universitaet Berlin, Bioinformatics programme and Max Planck Institute for Molecular Genetics, Germany. |
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| Abstract: | SUMMARY: By linking differential gene expression to the chromosomal localization of genes, one can investigate microarray data for characteristic patterns of expression phenomena involving sizeable parts of specific chromosomes. We have implemented a statistical approach for identifying significantly differentially expressed chromosome regions. We demonstrate the applicability of the approach on a publicly available data set on acute lymphocytic leukemia. AVAILABILITY: The R-package MACAT can be obtained from http://www.compdiag.molgen.mpg.de/software/macat.shtml SUPPLEMENTARY INFORMATION: http://www.compdiag.molgen.mpg.de/software/macat.shtml. |
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