Recognition of complex oligosaccharides by the multi-subunit asialoglycoprotein receptor. |
| |
| Authors: | H F Lodish |
| |
| Affiliation: | Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142. |
| |
| Abstract: | The hepatic asialoglycoprotein receptor, a galactose lectin, is an oligomer of two types of similar polypeptide chains, each of which weakly binds galactose. High-affinity binding of complex oligosaccharides requires a precise geometric arrangement of receptor subunits. The two subunits have different functions in receptor assembly, ligand binding and endocytosis. |
| |
| Keywords: | |
|
|
