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Integrated analysis of DNA copy number and gene expression microarray data using gene sets |
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| Authors: | Renée X Menezes Marten Boetzer Melle Sieswerda Gert-Jan B van Ommen Judith M Boer |
| Institution: | (1) Center for Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands;(2) Pediatric Oncology Laboratory, Erasmus Medical Center, Rotterdam, The Netherlands;(3) BioRange, Netherlands Bioinformatics Centre, Nijmegen, The Netherlands;(4) Center for Medical Systems Biology, Leiden, The Netherlands |
| Abstract: | BackgroundGenes that play an important role in tumorigenesis are expected to show association between DNA copy number and RNA expression. Optimal power to find such associations can only be achieved if analysing copy number and gene expression jointly. Furthermore, some copy number changes extend over larger chromosomal regions affecting the expression levels of multiple resident genes. |
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