我国实验小鼠群中巨细胞病毒自然感染情况的调查

迄今为止,有关MCMV在实验小鼠群中的自然感染情况报道极少。我们在MCMV实验感染的基础上对国内常用的小鼠品系进行MCMV自然感染的调查。结果发现在334份不同品系小鼠颌下腺中无1份分离出MCMV,而特异性抗体存在于所检查的10个品系中,阳性率为10.9—87.5％。抗体阳性率与鼠龄有关,随鼠龄的增长而上升。对全国部分省市40家实验动物机构的556份小鼠血清的调查结果表明MCMV的抗体阳性率达61.0％,提示在我国实验小鼠群中MCMV的自物感染是相当普遍的。这种病毒分离阴性而抗体阳性的状态表明隐性感染和潜伏感染是MCMV自然感染的主要方式。

A Survey on the Natural Infection of Murine Cytomegalovirus in Laboratory Mouse Colonies in China

Up to present, few was reported about the natural infection of murineeytomegalovirus(MCMV) in laboratory mice. Based on the experimental infection of MCMV, we made a survey on the natural infection of MCMV in 10 common used strains of mice It was found that of 334 samples of submaxllary gland homogenate, none were positive for viral isolation, whereas specific anti-MCMV antibodies were found in 10.9-87.50% of different strains of mice. There were tendencies of increase in antibody positive rates as the mice grew older A serological survey of 556 mouse sera from 40 laboratory animal institutions of some provinces showed that the antibody positive rate was as high as 61.0%, indicating that the natural infection of MCMV in laboratory mice was common in our country, The state of viral isolation negative-antibody positive suggested that the inapparent and 7atent infection were the main way of natural infection of MCMV