Early effect of 25-hydroxycholecalciferol (25-OH-D3) and 1,25-dihydroxycholecalciferol (1,25-(OH)2-D3) on the ability of parathyroid hormone (PTH) to elevate cyclic AMP of intact bone cells. |
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Authors: | A Mahgoub H Sheppard |
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Institution: | Department of Cell Biology, Research Division Hoffmann-La Roche Inc., Nutley, New Jersey 07110 USA |
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Abstract: | 25-OH-D3 and 1,25-(OH)2-D3 had no effects by themselves on the cyclic AMP levels of isolated bone cells but enhanced the stimulation seen following an exposure with submaximal concentrations of PTH for as little as 2 minutes. Preincubation with the 25-OH-D3 or 1,25-(OH)2-D3 resulted in a time dependent decrease in the enhancement of PTH response over a 1 hr period. It is, therefore, suggested that cyclic AMP may be involved in some aspects of the action of vitamin D3 derivatives on bone cells. |
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