Prostate cancer cells show elevated urokinase receptor in a mouse model of metastasis |
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| Authors: | Inder Sehgal Timothy P Foster and Joseph Francis |
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| Institution: | (1) LSU Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA;(2) LSU Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA |
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| Abstract: | Background The urokinase receptor (uPAR) governs several functions necessary during invasion and metastasis such as motility, degradation
of the extracellular matrix and adhesion. This receptor has been recently associated with clinical prostate cancer progression.
Experimentally, inhibition of uPAR reduces colonization of extra-prostatic sites in animal models. Our objective in this study
was to compare uPAR expression in orthotopic vs. metastatic foci in vivo and to examine at the cellular level how uPAR might promote early stages of metastasis. |
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