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Cytotoxic effects of zirconium oxychloride on bone marrow cells of mice |
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| Affiliation: | 1. Research Centre Jülich, Jülich, Germany;2. King''s College London, London, UK;3. TRIUMF, Vancouver, Canada;4. Uppsala University, Uppsala, Sweden;5. Brookhaven National Laboratory, Upton, USA;6. Keio University, Tokyo, Japan;7. Seoul National University, Seoul, South Korea;8. University of Pennsylvania, Philadelphia, USA;9. Ludwig Boltzmann Institute Applied Diagnostics, Vienna, Austria;10. National Institute of Mental Health, Bethesda, USA;11. VU University Medical Center, Amsterdam, the Netherlands;1. Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands;2. Department of Targeted Therapeutics, MIRA Institute, University of Twente, Enschede, The Netherlands;3. Department of Experimental Molecular Imaging, University Clinic and Helmholtz Institute for Biomedical Engineering, RWTH-Aachen University, Aachen, Germany;4. Department of Pharmaceutics, Utrecht Institute for Parmaceutial Sciences, Utrecht University, Utrecht, The Netherlands |
| Abstract: | A single oral administration of an aqueous solution of zirconium oxychloride to mice of both sexes in concentrations , , of LD50 induced chromosomal abnormalities in bone marrow cells. The frequencies of aberration were directly proportionate to the concentrations used. Female mice were found to be more susceptible than male mice, though not to a significantly higher level. This is the first report on the clastogenicity of this metal. |
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