Suppressing effects of vanillin,cinnamaldehyde, and anisaldehyde on chromosome aberrations induced by X-rays in mice |
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| Institution: | 1. Department of Physiology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt;2. Department of Pharmacology, University of Oxford, Oxford, UK;3. Department of Cardiology, Trinity College, Dublin, Ireland;4. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway;1. Kolling Institute, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia;2. Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, NJ 08854, USA;3. Charles Perkins Centre, Sydney Medical School, University of Sydney, New South Wales 2006, Australia;1. Department of Molecular and Cellular Sciences, Faculty of Advanced Sciences and Technology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran;2. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran;3. Department of Anatomical Sciences, Lorestan University of Medical Science, Khorramabad, Iran |
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| Abstract: | X-ray-induced chromosome aberrations were suppressed when vanillin, cinnamaldehyde, or p-anisaldehyde was given orally to mice after X-ray irradiation. Chromosome aberrations were monitored by the occurrence of polychromatic erythrocytes with micronuclei in bone marrow cells. The frequency of micronuclei was depressed about 55–60% without toxicity of the test compounds to the bone marrow. |
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