Inhibition of GSK-3 reduces infarct volume and improves neurobehavioral functions |
| |
Authors: | Koh Seong-Ho Yoo A Rum Chang Dae-Il Hwang Se J Kim Seung H |
| |
Affiliation: | a Department of Neurology, College of Medicine, Hanyang University, #17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Republic of Korea b Department of Neurology, College of Medicine, Kyung-Hee University, Seoul, Republic of Korea c Department of Anatomy, College of Medicine, Hanyang University, #17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Republic of Korea |
| |
Abstract: | In the present study, we have investigated the effects of glycogen synthase kinase-3 (GSK-3) inhibition on infarct volume and neurobehavioral functions in a focal cerebral ischemia model. To achieve our goals, GSK-3 inhibitor II or VIII was injected at several time points and in varing dosages. GSK-3 inhibitor VIII was more effective than inhibitor II, and infarct volume and water content in the VIII group were significantly decreased 24 h after the onset of ischemic stroke, as compared with the control group. These protective effects were associated with reductions of TUNEL-positive cells, neutrophil infiltration, glucose levels after ischemia, and GSK-3 enzyme activity. In addition, expressions of death and inflammation-related signals decreased and those of survival-related signals increased. Lastly, neurobehavioral functions were restored to a greater extent in the VIII group than in the control group. Together, these results suggest that GSK-3 inhibition reduces infarct volume and restores neurobehavioral functions. |
| |
Keywords: | Glycogen synthase kinase-3 Ischemia Stroke Inflammation Neuronal cell death |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|