Factors determining the formation and release of bioactive IL-12: regulatory mechanisms for IL-12p70 synthesis and inhibition |
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| Authors: | Zhang Sheng Wang Qin |
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| Institution: | a Medical Oncology, First People’s Hospital, Shanghai Jiaotong University, 85 Wujin Road, Shanghai 200080, China
b Department of internal cardiology, Songjiang central hospital,746 Zhongshanzhong Road , Shanghai,201600 China |
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| Abstract: | IL-12 is an important type 1 immune activation cytokine. It is known that macrophages and dendritic cells the major cell types producing this cytokine and that these cells may release both the biologically inactive form (IL-12p40) and active form (IL-12p70) of IL-12. In this review, the latest information regarding the regulatory mechanisms governing the production of IL-12p70 by these cells is evaluated. |
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| Keywords: | IL-12 Cytokine Dendritic cells |
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