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Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects |
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| Authors: | Lie Maria E. K. Kickinger Stefanie Skovgaard-Petersen Jonas Ecker Gerhard F. Clausen Rasmus P. Schousboe Arne White H. Steve Wellendorph Petrine |
| Affiliation: | 1.Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark ;2.Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria ;3.Department of Pharmacy, University of Washington, Washington, USA ; |
| Abstract: | Neurochemical Research - Focal epileptic seizures can in some patients be managed by inhibiting γ-aminobutyric acid (GABA) uptake via the GABA transporter 1 (GAT1) using tiagabine... |
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